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APIS® Synthetic Wound Matrix
Powerful yet simple relief for everyday chronic and acute wounds
APIS® is an advanced bioengineered wound care product for managing chronic, acute, and surgical wounds. Made with a collagen derivative, Manuka honey, and hydroxyapatite, APIS supports improved wound healing by covering and protecting the wound, absorbing exudate, and creating a moist wound environment. See a physician testimonial or view the APIS Clinical Case Book.
- 2x faster wound closure rates than the standard of care, even in stalled, chronic wounds.1-3*
- Lower pain scores in surgical wounds reported by patients.4*
- Powerful microenvironment support; inhibits gram-positive and negative bacterial growth (99.99% reduction in-vitro).5* Suppresses matrix metalloproteinase-9 (MMP-9) release from macrophages.6-7* Increases angiogenic growth factor secretion from fibroblasts, in vitro.6-7*
- Highly conformable sheet; maximizing contact within the wound bed.
- Sterile and shelf stable at room temperature; available in small sizes (1.6x1.6cm, 2.5x2.5cm, 5x5cm).
- 510(k) clearance #K222143: synthetic wound matrix indicated for acute (e.g., surgical) and chronic (DFU, VLU, PU) wounds.
In Vitro data demonstrates 99.99% (4 log) reduction in gram-positive and gram-negative bacteria5*
Comparison Chart*
REFERENCES
1. Rodriguez, et al., Novel bioengineered collagen with Manuka honey and hydroxyapatite sheet for the treatment of lower extremity chronic wounds in an urban hospital wound care setting. Wounds. 2023 Jan;35(1):E35-E38.
2. Rodriguez, et al., Preliminary Clinical Evaluation Using a Novel Bioengineered Wound Product to Treat Lower Extremity Ulcers. Int J Low Extrem Wounds. 2023 Mar;22(1):139-145.
3. McMurray, et al., Use of a Novel Biomaterial to Enhance Secondary Intention Healing. Available Wound Products: Collagen Sheet, Manuka Honey Sheet, and a Novel Bioengineered Collagen Derivative + Manuka Honey + Hydroxyapatite Sheet. 2021.
4. Arnaud, et al., Novel Biomaterial Containing Gelatin, Manuka Honey, and Hydroxyapatite Enhanced Secondary Intention Healing Versus Standard Secondary Intention Healing in Mohs Surgical Defects on the Head and Distal Lower Extremities-A Randomized Controlled Trial: Pilot Study. Dermatol Surg. 2023 Dec 1;49(12):1160-1164.
5. Williams, et al., A novel bioengineered wound product with in vitro capabilities to reduce bacteria. Biomed Transl Sci. 2021; 1(1):1-3.
6. Rodriguez, et al., Microenvironment influence of a novel bioengineered wound product APIS®: An in vitro analysis of inflammatory marker and growth factor secretion. Int J of Biomaterials, vol. 2021. 2021.
7. Rodriguez, et al., A Preliminary Direct Comparison of the Inflammatory Reduction and Growth Factor Production Capabilities of Three Commercially Available Wound Products: Collagen Sheet, Manuka Honey Sheet, and a Novel Bioengineered Collagen Derivative + Manuka Honey + Hydroxyapatite Sheet. Int J Mol Sci. 2022 Sep 14;23(18): 10670
*Based on clinical and in vitro data; claims have not been cleared by the FDA. Faster wound closure reported in slower healing and chronic wounds compared to standard of care.
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Key Features
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All necessary regulatory documentation, instructions for use, published studies, patient education tools, etc. (as applicable) can be provided upon request by contacting cs@spartanmedical.com or (888) 240-8091. We are available at any time to meet with providers and staff to answer any questions about Spartan Medical’s entire portfolio of advanced medical solutions.
